3q27 rearrangements in non Hodgkin lymphoma, t(3;Var)(q27;Var) in non Hodgkin lymphoma
نویسندگان
چکیده
Note 3q27 rearrangements occur in distinct clinicopathological entities of B-cell non Hodgkin lymphoma (NHL), including diffuse large cell lymphoma (DLCL), follicle centre cell lymphoma (FCCL) and marginal zone B-cell lymphoma (MZBCL) in the REAL classification; very rare cases were also reported with mantle cell lymphoma and chronic lymphocytic leukemia. 3q27 breaks are usually, but not invariably, associated with rearrangements of the BCL6 gene located at the 3q27 chromosome band; likewise rearrangements of this gene may occur without detectable 3q27 breaks.
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Molecular cloning of the breakpoint for 3q27 translocation in B-cell lymphomas and leukemias.
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